Gastrointestinal disorders (FGIDs) affecting up to 40% of individuals, characterized by chronic digestive symptoms without clear structural causes. Rasayana therapy from Ayurvedic medicine is explored as a novel strategy for enhancing cell-mediated immunity and managing FGIDs. The literature search focused on Rasayana therapy's impact on gastrointestinal health and disease prevention, integrating clinical trials and experimental studies. Rasayana formulations like Chyawanprash and Ashwagandha demonstrate significant immunomodulatory effects, activating immune cells and balancing cytokines to support immune homeostasis in the gastrointestinal tract. These formulations also possess antioxidant properties crucial for gut health and immune function. Clinical studies provide strong evidence of Rasayana therapy's efficacy in improving immune responses and managing FGIDs.