Katepurna Wildlife Sanctuary, located in Akola district of Maharashtra. It harbours rich biodiversity including several underutilized plant species with significant nutritional and medicinal potential. Despite their availability, these plants remain neglected in mainstream diets and healthcare practices. The present study documents and theoretically evaluates the nutritional profiles and ethnomedicinal uses of underutilized species in the sanctuary. Field surveys, ethnobotanical interviews with local communities, and literature reviews were conducted. A total of 11 species belonging to 9 families were identified. Species such as Amranthus spinosus, Boerhavia diffusa, Buchanania lanzan, Butea monosperma, Cassia tora, Cleome viscosa, Cordia dicotoma, Dioscorea bulbifera, Mucuna prurience, Ruellia tuberosa, Zizipua mauritiana were found rich in micronutrients and bioactive compounds. The study highlights the potential of these species in addressing malnutrition, lifestyle diseases, and promoting sustainable use of local biodiversity.