Abstract: Cardiovascular diseases (CVDs) represent a major health burden globally, necessitating effective pharmacological and nutritional interventions. Polyphenols, a diverse group of phytochemicals abundant in fruits, vegetables, and beverages, have garnered attention for their potential impact on cardiovascular health. This paper explores the influence of polyphenols on drug metabolism and efficacy within the context of cardiovascular disease management. Polyphenols are known to interact with drug-metabolizing enzymes and transporters, potentially altering the pharmacokinetics and pharmacodynamics of cardiovascular drugs. These interactions may lead to significant changes in drug absorption, distribution, metabolism, and excretion, which can influence therapeutic outcomes and patient safety. By reviewing current literature, this study aims to elucidate the mechanisms through which polyphenols modulate drug metabolism and their implications for clinical practice. Emphasis is placed on the role of specific polyphenolic compounds, such as flavonoids and phenolic acids, in affecting enzyme activity and drug interactions. Additionally, the paper discusses the potential for polyphenols to enhance or diminish the efficacy of cardiovascular medications and their overall impact on patient management. The findings highlight the need for healthcare providers to consider polyphenol intake when prescribing cardiovascular therapies to optimize treatment outcomes and minimize adverse effects. Future research directions are proposed to better understand the complex interactions between polyphenols and cardiovascular drugs, with the goal of improving personalized medicine strategies for CVD management.