IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

Synthesis and Antibacterial Activity of Novel Dehydrodiisoeugenol Derivatives

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Vijay D. Gangan and Uttam Yadav

Abstract

Dehydrodiisoeugenol constitute a new group of antimitotic and potential anti-cancer agents that inhibit tubulin polymerization. It is a dihydrobenzofuranoid type neolignan have been synthesized and diversified to its respective ether using conventional method (K2CO3/R-Br/acetone; R = alkyl, aralkyl) and characterized by 1H NMR, IR, elemental analysis and mass spectral data. These synthesized compounds were screened for their potential antibacterial activity against Gram-positive and Gram-negative bacteria. Few of them displayed promising antibacterial activity. All these compounds were new and confirmed by Scifinder search.

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