The indigenous knowledge system of the tribes of Wayanad represents a symbiotic relationship between humans and nature, passed down through generations as oral traditions and practices. This paper explores the unique aspects of tribal house construction, medicine, food practices, and agricultural techniques in Wayanad, a region known for its rich biodiversity and cultural heritage. The study emphasizes how these practices are rooted in sustainability, community welfare, and the preservation of natural resources. The paper also highlights the challenges these knowledge systems face due to modern development and the need for their preservation in the context of global environmental concerns.