This article gives a brief introduction to the Aluminium (Al), Al and its effects, several of organs. The physical and chemical properties of Al, where it naturally by occurs, its production, uses as well as the kinetic & metabolism of Al are also discussed in detail. Present study reported that Al chloride capable of caused marked alterations in some biochemical parameters. Significant decrease was found in the levels of glutathione peroxidase, catalase, superoxide dismutase, and increased level was observed in TBARS in brain. Al alterations on major biochemical constituents such as proteins, nucleic acids and glycogen along with phosphodiester linkages, tryptophan bands, tyrosine doublet, disulfide bridge conformations, aliphatic hydrophobic residue, and salt bridges lipids and nucleic acids due to the overproduction of ROS in brain, liver, kidney, spleen, bone tissues of mice. The administration of deferiprone and deferoxamine and deferiprone significantly improved the level of protein, and recovered the progression of Al induced Alzheimer‟s disease. Al toxicity is a wide spread crisis in all living organisms, including both flora and fauna, furthermore causes wide spread degradation of the environment and health. DFO and DFP are efficient chelators for Al poisoning and they reduce the Al concentration. Ca, Mg, and P contents of the Al exposed bone were less than those of the control group, and there was an increase in the mineral contents of the bone after DFO and DFP treatments.