Sikkim, a biodiversity-rich state in northeastern India, is home to over 490 medicinal plant species used in traditional folk medicine by local communities. This study explores the importance and uses of some key medicinal plants in Sikkim, highlighting their therapeutic properties and roles in local healthcare systems. The folk medicinal practices of Sikkim have been passed down through generations and are deeply intertwined with cultural and religious traditions. This article reviews several medicinal plants, such as Titepati (Artemisia indica), Chiraito (Swertia chirayita), and Cardamom (Amomum subulatum), and examines their applications in treating common ailments such as digestive disorders, respiratory issues, and skin problems. Additionally, these plants contribute to the preservation of Sikkimese cultural heritage and provide affordable healthcare options, particularly in rural communities