The management of type 2 diabetes mellitus (T2DM) relies heavily on diet. It is proposed that intermittent fasting (IF) is a novel strategy that has the potential to improve glucose control and reverse some of this condition's pathophysiological changes. The molecular and clinical evidence of diets based on intermittent energy restriction (IER) in type 2 diabetes patients and laboratory animal models is discussed in this review. In addition, we look at how IF is thought to reverse cell failure and improve glucose homeostasis. The 2021 agreement report on the definition and translation of reduction of type 2 diabetes (T2D) has been delivered. Despite the growing popularity of intermittent fasting diets (IF), no studies have examined their effectiveness in diabetes remission [1].