The research was undertaken with the object to develop the fortified health drink using cotton seed milk blended with kale and other ingredients. The aim of our present study was to fortify the vitamin A, K, C in Health Drink using Kale leaves powder to avoid the vitamin deficiency. The ingredients used for the preparation of fortified Health Drink was optimized by using Minitab 18. The fortified health drink was analyzed for physio-chemical properties, microbial analysis, and sensory analysis. Physio-chemical properties like Total soluble solids, Ascorbic acid, Moisture Content, Carbohydrate, Fiber, Protein, fat, pH, acidity and Ash were studied. The Protein and Fat slightly decreased due to Enzymatic oxidation. The increase in total solids was due to the loss of moisture. The Acidity of sample was increased significantly while there was a decrease in pH during storage. The decrease in Fiber occurs due to its storage period and exchange of free radicals. The optimum conditions for the best sensory score of the outputs obtained were Cotton seed milk- 970g, Kale leaves powder-75g, Palm Sugar- 178g, and Corn flour-52 g. The overall scores were 8.0.