Modern medicine has made a significant contribution to humanity's ability to combat a wide range of infectious illnesses. People have shifted their focus back to natural remedies since traditional medication has a reputation for having a plethora of side effects, many of which are mild to nonexistent. The use of herbal remedies to treat infectious illnesses has been around since the beginning of time and has been shown to be a viable option. However, their limited bioavailability and solubility limit their practical use. More effective options have been found in the form of plant-based nanoparticles, which have been shown to boost bioavailability and solubility of herbal medications. For this review, nanotechnology systems will be highlighted as a new drug delivery method for herbal medicines to increase the therapeutic benefits and bioavailability of naturally occurring medications. Also discussed are how to make herbal nanoparticle formulation, their structure and how to employ herbs in conjunction with nanoparticles. It is expected that this comprehensive study of biomedical science will serve as a springboard for new research and applications in the field. PubMed, Google Scholar, and Medline were used to gather information.