IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

MOLECULAR DOCKING STUDY OF THE PACHAI KARPOORA MATHIRAI COMPOUNDS TARGETING SARS COV-2 RNA DEPENDENT RNA POLYMERASE(nsp12)

Main Article Content

Dr.R.Saraswathi,Dr.A.Elavarasi

Abstract

Pachai karpoora mathirai traditionally used to treat all type of fever .The covid -19 has now been declared a global pandemic by WHO.No approved drug is currently available so need to developed anti viral theraphy for covid -19 .Pachai karpoora mathiar effective against covid symptoms of fever, cough,sore throat,shortness of breath,body ache, abdominal bloating ,loss of smell,loss of taste and constipation.The present study aims to identify molecules from Pachai karpoora mathirai sars –cov-2 RNA-dependent RNA polymerase(RdRp) inhibitors by molecular docking study. Binding of phytocomponents with the core amino acids (618 ASP, 760 ASP, 761 ASP) of the targets by forming hydrogen bond will hinder the function of the targets RNA dependent RNA polymerase (PDB)-6NUR possess versatile action in mediating nonstructural protein (nsp 12) essential for viral replication. Thereby phytocomponents in Pachai karpoora mathirai which inhibit the target RdRp may act as a potential therapeutic agent for management of COVID-19 and related symptoms.

Article Details