Lambda-cyhalothrin is a synthetic type II pyrethroid, insecticide used worldwide in agriculture, home pest control, protection of food stuff and disease vector control. The present study was under taken to evaluate the influence of long term intoxication of mice with sub toxic doses of Lambda cyhalothrin on the activity of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and Lipid peroxidation in selected tissue Liver and Kidney of Albino mice