This systematic review explores the impact of dietary patterns on cardiovascular health by synthesizing evidence from a range of studies. Cardiovascular diseases (CVD) pose a significant global health burden, and understanding the role of dietary habits is crucial for prevention and management. The review includes analyses of cohort and case-control studies, examining diverse populations and employing various dietary assessment methods. Key findings reveal that healthier dietary patterns are associated with a reduced risk of cardiovascular endpoints, with a particular emphasis on the Mediterranean diet. The review also addresses the challenges of studying unhealthy or Western dietary patterns, highlighting the complexity of associations with specific CVD outcomes. Methodologically, the review evaluates the robustness of study designs, sampling techniques, and statistical methods used across the literature. It underscores the importance of representative sampling, adequate sample sizes, and valid dietary assessments for meaningful conclusions. Furthermore, the review considers the role of biomarkers in elucidating the relationship between dietary patterns and cardiovascular outcomes. Dietary pattern analysis emerges as a critical aspect, with a focus on identifying patterns that transcend individual nutrients. The cultural and regional variations in dietary choices are acknowledged, emphasizing the need for tailored interpretations in diverse populations