Treatment and management for SARS COV-2 were doubtful in the initials of the corona pandemic. The health system was preparing itself to tackle the rapidly evolving pandemic. The potential of Ayurveda, which is one of the 5000-year-oldbranches of traditional Indian medicine (TIM)systems, employing medicines obtained from plants and other natural sources, for SARS-COV 2 has been explored by this comparative and open-label retrospective study. Methods: Here we reported the medicinal effects of Ayurvedic medicines along with Allopathic drugs on 50 COVID-19 patients with mild symptoms, in one of the hospital of Lucknow. The cases were diagnosed with COVID-19 infection by RT-qPCR of nasopharyngeal swabs and throat swabs. Informed consent was taken from the patients, and the data were categorized into ‘Allopathic plus Ayurvedic’ (n = 25) and ‘Allopathic only’ (n = 25) groups, on the basis of the type of therapy the patients decided to receive, that is Ayurvedic along with Allopathic medicines or Allopathic medicines only, respectively. Ayurvedic medicines were given in oral forms extract of Tinospora cardifolia. The Allopathic drugs given were Acetamphinone, VitaminC, Zinc, Azithromycin, Ivermectin, and anti-histamines. All patients of both groups were observed for symptomatic relief. Results: The key outcome of this research was the symptomatic improvement from SARS-COV-2. Data gathered for a period of one month, showed a greater number of patients exhibiting symptomatic relief in Allopathic plus Ayurvedic’ (80.33 %) than in the Allopathy group (60.78 %) within the first 10 days of treatment. There was no significant side effect observed. This was found that early and safe symptomatic relief among patients treated with Ayurvedic plus Allopathy medicines. Food and nutrition value of Tinospora cardifolia was also benefitted to the patients in early outcome. Conclusion: Covid-19 patients receiving Allopathic along with Ayurvedic medicines on average were symptomatically improved faster in comparison to those receiving Allopathic medicines only.