This article delves into the analysis of boundary layer flow of MHD Casson Nanofluid over an inclined extending surface, considering thermal radiation, heat source/sink, Soret and Dufour effects. The study employs the Buongiorno model, incorporating Brownian motion and thermophoresis properties to explore the thermal efficiencies of fluid flows. The nonlinear problem concerning Casson Nanofluid flow over an inclined channel is formulated to gain insights into heat and mass exchange phenomena. Key flow parameters of the intensified boundary layer are considered. The governing nonlinear partial differential equations are transformed into ordinary differential equations, subsequently numerically solved using the homotopy analysis method (HAM). Numerical outcomes, along with graphical representations in tables and graphs, are presented. It's observed that an increase in the inclination parameter leads to reduced surface friction, but conversely affects the Nusselt number and Sherwood number. The concentration field demonstrates a decreasing trend with the inclination parameter, whereas the chemical reaction rate parameter exhibits an opposite increasing trend. These findings align remarkably well with previous studies conducted by other researchers.