A simple, rapid, accurate, and cost-effective RP-HPLC method was devised to estimate praziquantel and ivermectin in combination tablet dosage form. Chromatography was conducted using a Cosmosil C18 column (250 mm x 4.6 mm, particle size: 5 microns), with a mobile phase consisting of methanol and HPLC grade water in a ratio of 80:20 v/v, along with O-phosphoric acid to adjust the pH to 3. The flow rate was set at 1.0 ml/min, and the detection was done at 223 nm. The retention times were found to be 4.757 ± 0.10 min for praziquantel and 6.751 ± 0.10 min for ivermectin. The method shows a linear response when the concentration is between 25-125µg/ml for Praziquantel and 1-5µg/ml for Ivermectin. The method was validated using parameters such as accuracy, precision, linearity, limit of detection and quantitation as well as robustness.