IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

Examination and Contrast the Adverse Effect Profiles of Various Iron Preparations

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Dr. Jyotsna Sharma1*, Dr. Shaktibala Dutta2 , Dr. Vaishali Lote3

Abstract

Background: Iron deficiency is the most widespread single dietary deficit in the world,1 affecting more than a third (more than 2 billion) of the worldwide population. 2 As a result of their increased iron needs, pregnant women are especially prone to iron deficiency and irondeficiency anaemia. In underdeveloped nations, the prevalence of iron-deficiency anaemia in pregnant women ranges from 35 to 75% (mean: 56%), whereas it averages 18% in prosperous nations. 3, 4 India reports an incidence rate of 87% in Central Asia, where the incidence rate is quite high. An estimated ninety percent of cases of anaemia in India are attributable to iron deficiency. Aim’s & Objectives: To study and compare adverse effect profile of various iron preparations prescribed. Materials & Methods: The study protocol was submitted to the Institutional Ethics Committee (IEC) for review and approval. After receiving approval from the appropriate authorities, the study was conducted on 120 pregnant women between the ages of 18 and 35 who attended the antenatal clinic at Santosh Medical College and Hospital in Ghaziabad. The research was done over the course of one year, from 11 August 2011 to 12 July 2012. Results: Compliance with Ferrous ascorbate was much greater at 73% compared to compliance with Ferrous fumarate (61.7%) and Carbonyl iron (55.4%). The incidence of adverse effects associated with oral iron preparations was 54.4% overall. These differences were statistically significant. The group with the highest occurrence was Carbonyl iron (61.5%), followed by Ferrous fumarate (57.6%) and Ferrous ascorbate (45.6%). Conclusion: This study was conducted to evaluate the efficacy, safety, and tolerability of three iron preparations: ferrous fumarate, ferrous ascorbate, and carbonyl iron. The traditional and economical iron preparation is ferrous fumarate. Ferrous ascorbate and Carbonyl iron are two novel iron preparations that are purportedly more effective and have a better tolerability profile than classic iron preparations, Ferrous sulphate and Ferrous fumarate.

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