The objective of this study was to evaluate the antibacterial activities of Curculigo orchioides using different solvent extracts. The antibacterial activities were determined against human pathogens viz. Klebsiella pneumoniae, Escherichia coli, Proteus vulgaris, Salmonella typhi and Staphylococcus aureus. The highest value observed from N butyl alcohol extracts of Curculigo orchioides showed antibacterial activity against Klebsiella pneumoniae (inhibition zone 21mm). Moreover, the bioactivity exhibited showed a wide variation among the selected pathogens with the plant extracts were studied. All the tested human pathogens were highly sensitive to ciprofloxacin with the zone of inhibition above 33 mm. Further study is necessary to detect and evaluate the actual constituents responsible for the antibacterial activity of the valuable medicinal plant investigated for its successful utility.