Experiment titled Effect of vermicompost and NPKS on growth, yield and yield components of Red Amaranthus during Rabi Season 2022-2023 was conducted at the research farm of the Department of Horticulture, AKS University, located in Satna (MP). Employing a randomized block design, the experiment comprised twelve treatments, each repeated thrice viz., T1: Without Fertilizer (Control), T2: Vermicompost @ 2.5 t/ha, T3: Vermicompost @ 5.0 t/ha, T4: Vermicompost @ 10.0 t/ha, T5: 50% NPKS, T6: 100% NPKS, T7: Vermicompost @ 2.5 t/ha + 50% NPKS, T8: Vermicompost @ 5 t/ha + 50% NPKS, T9: Vermicompost @ 10 t/ha + 50% NPKS, T10: Vermicompost @ 2.5 t/ha + 100% NPKS, T11: Vermicompost @ 5 t/ha + 100% NPKS, T12: Vermicompost @ 10 t/ha + 100% NPKS. The results reveal that the utilization of Vermicompost at a rate of 10 tons per hectare combined with 100% NPKS resulted in superior growth yield, alongside quality enhancement. Consequently, the application of these nutrients could be embraced in the semi-arid eastern plain zone of Madhya Pradesh. Nonetheless, it is crucial to note that these results are preliminary and necessitate additional experimentation for achieving more consistent and conclusive outcomes before being disseminated to growers.