Periodontitis is a multifactorial, chronic inflammatory condition that affects theoral cavity and has been linked to anaemia. Anaemia of chronic disease is the second most prevalent serious health condition that affects people of all sexes and ages. Anaemia is considered as one of the etiological factors of periodontitis and a chronic periodontitis can be as risk factor for anaemia. The aim of the present was to evaluate erythrocyte parameters among chronic periodontitis patients. Method: Total200 subjects were included in the study. Group I: 50 systemically healthy males with healthy periodontium, Group II- 50 Systemically healthy males with chronic periodontitis, Group III: 50 Systemically healthy females with healthy periodontium and Group IV: 50 Systemically healthy females with chronic periodontitis. Erythrocyte parameters (HCT/PCV, MCV, MCH, and MCHC) and ESR were evaluated from venous blood samples. Results: Erythrocyte parameters were found to be decreased among both male and female chronic periodontitis patients compared to their periodontally subjects. The level of significance was set at p≤ 0.005. Conclusion: It can be concluded based on the results that, like any other chronic condition, chronic periodontitis can also lead to anemia.