IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

Assessment of Antidiabetic Activity of Silver Nanoparticles Using Gracilaria Edulis Seaweed Extract – An in Vitro Study

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Samivel Chelliah , Vasugi Swamivel Rathinavelu , Krishnamoorthy Palaniyandi

Abstract

Diabetes mellitus is a significant challenge to public health. It is distinguished by an abnormality in the metabolism of carbohydrates as well as a manufacturing deficiency in insulin, which leads to an elevated concentration of glucose in the blood. These metabolic changes lead to immediate as well as long-term problems associated with diabetes. The majority of different types of seaweed contain diabetes-fighting compounds such as alkaloids, glycosides, terpenoids, and flavonoids, and research has shown that these compounds are both safe and beneficial in treating diabetes. An attempt has been made to create silver nanoparticles with the seaweed, and the antidiabetic activity of these particles has been investigated in vitro. In humans, the enzymes amylase and glucosesidase play an important role in the digestion of dietary carbohydrates. Inhibitors of these enzymes may be useful in preventing postprandial hyperglycemia by delaying the digestion of carbohydrates and the absorption of glucose. In this study, a green synthesis of silver nanoparticles was performed using Gracilaria edulis seaweed, and the anti-diabetic effect of the green synthesized nanoparticles was evaluated in vitro. Both alpha-amylase and alphaglucosidase were inhibited by the AgNPs at a rate that was statistically significant. The effectiveness of the biosynthesized nanoparticles was much better than that of the Gracilaria edulis extract

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