Operational transconductance amplifiers (OTAs) are fundamental building blocks in various analog and mixed-signal circuits, with applications ranging from audio amplification to bio-signal processing. The efficiency and performance of OTAs are crucial, especially in low-power applications like portable bio-signal processing devices. This paper introduces a novel Low Power Bulk-Driven OTA designed specifically for bio-signal processing, addressing the pressing need for power-efficient solutions in the field of healthcare and biomedical engineering. The proposed OTA leverages the bulk-driven technique, a relatively less explored design approach, to optimize power consumption while maintaining adequate performance characteristics. This technique capitalizes on the nonlinearity inherent in metal-oxide-semiconductor field-effect transistors (MOSFETs) and exploits it to enhance the gain and transconductance of the amplifier. This innovative approach offers several advantages in the context of bio-signal processing. The architecture of the Low Power Bulk-Driven OTA is detailed in this paper, with a focus on the key design principles that enable its superior power efficiency. By carefully selecting the device parameters and biasing conditions, the amplifier is tailored to operate efficiently in the subthreshold region, where power consumption is significantly reduced. Furthermore, the architecture includes provisions for compensating the inherent nonlinearities associated