The research article provides an overview of the effectiveness of a “structured teaching program” (STP) in improving the knowledge and attitude of antenatal mothers towards antenatal care during COVID-19. Focusing on the care of antenatal mothers admitted at Narayana Medical College Hospital, Nellore, Andhra Pradesh, the research outcomes helped bring out specific aspects of structured teaching to improve antenatal care and mitigate the chances of COVID-19 infection. 60 antenatal mothers admitted at the OPD of NMCH, Nellore were taken as the study’s sample and a structured questionnaire was formed to assess the participants’ knowledge regarding antenatal care during COVID-19. Findings revealed that STP significantly helped antenatal mothers improve their knowledge and attitude towards maternity care and prevent chances of infection.