Diabetes is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Insulin is a hormone that regulates blood sugar. Insulin is a hormone secreted by beta cells which are one of the four types of cells in the islets of langerhans in the pancreas. Insulin is considered to be a life-saving drug; however, regular accessto low-cost insulin – particularly the newer analogue types – may be reduced in economically poor countries and individuals.Data collected by WHO 2016-2019 from 24 countries on four continents showed that human insulin wasavailable only in 61% of health facilities and analogue insulin in 13%. The data showed that’s month’ssupply of insulin would cost worker in Accra, Ghana, the equivalent of 5.5 days of pay per month, all 22% of his/her earnings. Objective Of The Study:Assess the knowledge level regarding insulin administration among B.Sc nursing 2nd year students atEra College of Nursing, Lucknow. Evaluate the effectiveness of Structured Teaching Programme on knowledge regarding insulinadministration among B.Sc Nursing 2nd year student at Era College of Nursing, Lucknow.To find out the association of level of knowledge about insulin administration with their selecteddemographic variables. Research Methodology:This study was conducted using Quantitative Research approach at Era College of Nursing, Lucknow. Pre-experimental one group pre-test, post-test design was used in this study.The conceptual framework used in this study was Modified Kings Goal Attainment Theory. The total sample size was 30 selected by convenient sampling technique. The data was collected by administrating Structured Knowledge Questionnaire followed by Structured Teaching Programme about Insulin Administration. After 7 days, post-test was done to assess the effectiveness of STP.Results: The data obtained are tabulated and analyzed using descriptive and inferential statistics. The statistically analysis of data shows that 7 samples (23.33%) had adequate knowledge, 17 samples (56.67%)had moderate knowledgeand 6 samples (20%) had inadequate knowledge.The mean Pre-test knowledge score was (15.73) with standard deviation (6.84) and standard error (1.24). After giving Structured teaching Programme the score was increased to (24.16) with standard deviation (3.45) and standard error(0.629). The significance of Structured Teaching Programme regarding administration of insulin was assessed by using paired t-test (dependent t-test). The calculated t value for knowledge regarding administration of insulin is 13.62 is highly significant with degree of freedom is 29 at p<0.05 which shows that STP was effective for improving the knowledge among B.Sc Nursing 2nd year students. Conclusion: The finding revealed that there was a significant improvement in knowledge of B.Sc Nursing 2nd year students in post test after structure teaching programme. It showed that there was anassociation with post-test knowledge and selected demographic variable like Age, Previous knowledge regarding insulin, Knowledge regarding administration of insulin.