IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

A COMPREHENSIVE LITERATURE REVIEW ON THE THERAPEUTIC POTENTIAL OF MEDICINAL HERBS (ASHWAGANDHA, GILOY) IN THE MANAGEMENT OF PARKINSON'S DISEASE: RECENT DEVELOPMENTS

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Akhilesh Kumar, Neha Sirvastava, Nishant Singh Katiyar, Chandan Kumar Singh

Abstract

Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, resulting in motor and non-motor impairments. As conventional treatments often exhibit limitations, there is a growing interest in exploring alternative therapeutic options, including medicinal herbs. This literature review aims to provide a comprehensive overview of recent developments in the utilization of two prominent medicinal herbs, Ashwagandha (Withania somnifera) and Giloy (Tinospora cordifolia), in the context of Parkinson's disease. The review synthesizes findings from a range of preclinical and clinical studies, elucidating the neuroprotective and neuroregenerative properties of Ashwagandha and Giloy. Both herbs have demonstrated anti-inflammatory, antioxidant, and anti-apoptotic effects, suggesting potential benefits in mitigating the underlying mechanisms of neurodegeneration in PD. Furthermore, the review explores the modulation of neurotransmitter systems, particularly dopamine, by these herbs, highlighting their potential to ameliorate motor symptoms associated with Parkinson's disease.

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