BACKGROUND: Ekakustha has been described as Kshudra Kustha .In Ayurveda, all skin diseases have been described under umbrella of kushtha. Eka-Kushtha can be accepted as psoriasis because of its distribution pattern and features like Aswedanam Mahavastu. Matsyashakalopamam. Worldwide prevalence of psoriasis is 3%.In India its prevalence is 0.4%-2.8%. Frequent Shodhana is main treatment protocol mentioned by Acharya Charak.So,in this study Shodhana procedures such as Vamana, Virechana has been taken in the study with a particular Vamana Yoga, Virechana Yoga mentioned by Acharya Charak in Kustha disease. After Kostha-Shodhana ,Snehpana is must in kusthi as per Charak so, Tiktashatpal Ghrita has been taken in the study as Shamana drug after Shodhana. AIM: To evaluate and compare the efficacy of Vamana &Virechana along with Tiktashatpal Ghrita and Tiktashatpal Ghrita alone in the management of Ekakushtha. MATERIALS AND METHODS: Total 45 patients of Ekakustha were clinically diagnosed and in 15 patients Vamana was conducted followed by Tiktashatpal Ghrita for 30 days. In 15 patients Virechana was conducted followed by Tiktashatpal Ghrita for 30 days. In 15 patients only Tiktashatpal Ghrita was given for 30 days. Pre and post assessment was done on haematological and biochemical examination, PASI Score, Symptoms Score. RESULT: All the groups showed highly significant or significant results on nearly all the symptoms.There was not many significant difference found between three groups when groups were compared.However there was significant difference found between Vamana group and Shamana Group in symptoms such as Pitting, Unnati and Sleeplessness. According to PASI score Group A, B showed highly significant results whereas Group C showed significant result. No statistically significant change in haematological values, Biochemical values was found after treatment except statistically significant decrease in ESR (12.48 %) (p < 0.04) in group C.and significant decrease in SGOT (13.14%) (p < 0.05) in group A. The overall effect of therapies showed that, maximum number of patients (53.33%) had markedely improved in Group A, maximum number of patients (46.6%) had moderately improved in Group B and maximum number of patients (40%) had moderately improved in Group C. CONCLUSION: Based on the overall effect of therapy and PASI score it can be concluded that Vamana karma with Tiktashatpal ghrita provided better clinical management for psoriasis than Virechana with Tiktashatpal ghrita or Tiktashatpal ghrita alone.