The intersection of Human Resource Management (HRM) and Social Work within non-profit organizations represents a dynamic and underexplored field. This paper examines the unique challenges and opportunities at this juncture, emphasizing the dual need to balance employee well-being with organizational mission-driven goals. Using a mixed-methods approach, the study explores how HRM practices can support the values and ethics inherent in social work while enhancing operational efficiency and sustainability in non-profits. Key themes include recruitment strategies aligned with social justice, employee retention amidst resource constraints, and the integration of trauma-informed approaches into workplace policies. Findings reveal that harmonizing HRM and social work principles fosters an inclusive, supportive environment that promotes both employee satisfaction and service delivery outcomes. The paper underscores the potential of this synergy to enhance organizational impact, advocating for strategic frameworks that prioritize collaboration between HR professionals and social workers. Implications for policy, practice, and future research are discussed.