The interaction between dietary fiber and drug absorption is a critical aspect of pharmacokinetics that can influence therapeutic efficacy. This study explores the impact of dietary fiber on drug absorption and metabolism, focusing on the pharmacokinetic parameters such as bioavailability, half-life, and peak plasma concentration. Dietary fiber, particularly soluble fiber, forms a gel-like substance in the gastrointestinal tract, which can impede drug dissolution and slow down the absorption rate. This alteration in drug absorption may lead to reduced bioavailability, thus necessitating adjustments in drug dosage for effective treatment. Additionally, the presence of fiber can affect the metabolic enzymes, particularly those involved in first-pass metabolism, leading to alterations in drug clearance and half-life. By analyzing various drug-fiber interactions, the study reveals the complex nature of dietary fiber's influence on pharmacokinetics, highlighting the need for personalized drug dosing in patients with high fiber intake. The results indicate that certain drugs, especially those with narrow therapeutic windows, are more susceptible to these interactions, which could lead to subtherapeutic or toxic effects. The study emphasizes the importance of considering dietary habits, particularly fiber intake, in drug therapy planning to ensure optimal therapeutic outcomes. This analysis provides a foundation for future research on dietary fiber's role in drug metabolism and the development of guidelines for healthcare providers to manage drug-fiber interactions effectively.