IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

Synthesis And Biological Evaluation of Newly Substituted 2-Chloro-9-H-Carbazole-3-Carbaldehyde Derivatives as Potent Anticonvulsants

Main Article Content

A. Tiwari, B. Mishra, S. K. Gupta, G Venkata Nagaraju

Abstract

(E)-N-((2-chloro-9H-carbazol-3-yl) methylene) benzylamine derivatives were synthesized by using the vielsmeier-Haack reagent and evaluated for Anticonvulsant activity by using Maximal Electroshock (MES) method. In the first step, 2-chloro-9-H-carbazole-3-carbaldehyde formed via vielsmeier-Hack reaction in the presence of carbazole and vielsmeier reagent (DMF and POCl3). In a second step further reaction of carbaldehyde with different types of substituted aniline(3a-g) for the synthesis of ((E)-N-((2-chloro-9H-carbazol-3-yl) methylene) benzylamine) (4a-g). The substituted derivative was identified by TLC, FT-IR, and 1H NMR. All derivatives were evaluated for anticonvulsant activity in which compound 4e ((E)-N-((2-chloro-9H-carbazol-3-yl) methylene) benzenamine) showed maximum response as compared to standard phenytoin drug. The rest of the compounds (4a-d &f-g) showed mild to moderate response for anticonvulsant activity.

Article Details