Volume 13 | Issue 4
Volume 13 | Issue 4
Volume 13 | Issue 4
Volume 13 | Issue 4
Volume 13 | Issue 4
(E)-N-((2-chloro-9H-carbazol-3-yl) methylene) benzylamine derivatives were synthesized by using the vielsmeier-Haack reagent and evaluated for Anticonvulsant activity by using Maximal Electroshock (MES) method. In the first step, 2-chloro-9-H-carbazole-3-carbaldehyde formed via vielsmeier-Hack reaction in the presence of carbazole and vielsmeier reagent (DMF and POCl3). In a second step further reaction of carbaldehyde with different types of substituted aniline(3a-g) for the synthesis of ((E)-N-((2-chloro-9H-carbazol-3-yl) methylene) benzylamine) (4a-g). The substituted derivative was identified by TLC, FT-IR, and 1H NMR. All derivatives were evaluated for anticonvulsant activity in which compound 4e ((E)-N-((2-chloro-9H-carbazol-3-yl) methylene) benzenamine) showed maximum response as compared to standard phenytoin drug. The rest of the compounds (4a-d &f-g) showed mild to moderate response for anticonvulsant activity.