Numerous scientific studies all over the world are being carried out to develop secure and reliable ways of treating Diabetes Mellitus, a common endocrine disorder that causes many other microvascular and macrovascular problems. Being a common and chronic health problem with various adversities, different medical procedures are utilized in this treatment to ensure better no side-effect recovery. In the present study, a balanced comparison is composed on the basis of significant existing researches and approaches done in the field of medicines for hypoglycemic effects via natural and synthetic drugs. Sole purpose of this review article is to assess efficacy of natural and synthetic drugs for diabetes treatment and sort their advantages and shortfalls. A comparative approach is utilized with an aim to provide optimal diabetes treatment model that brings fast recovery with no long term drug dependency or no possibilities of adverse associated damages as hypoglycemia as observed in certain diabetes cure processes.