Micronutrient deficiencies represent a significant public health issue globally, impacting various physiological functions, including drug metabolism. Essential vitamins and minerals such as zinc, iron, and vitamins B6 and B12 play crucial roles in the enzymatic processes involved in drug absorption, distribution, metabolism, and excretion. This interplay between micronutrients and pharmacokinetics has profound implications for both nutritional and pharmacological interventions. Deficiencies in micronutrients can alter the activity of drug-metabolizing enzymes, leading to altered drug efficacy and increased risk of adverse drug reactions. For instance, zinc deficiency can impair the function of cytochrome P450 enzymes, which are essential for the metabolism of numerous pharmaceuticals. Similarly, iron deficiency can impact the bioavailability and efficacy of certain drugs due to its role in redox reactions. Nutritional interventions aimed at addressing these deficiencies could enhance drug efficacy and reduce side effects, thereby improving therapeutic outcomes. Conversely, personalized pharmacological approaches that consider an individual's micronutrient status can lead to more effective and safer drug therapies. This abstract explores the intersection of micronutrient deficiencies and drug metabolism, emphasizing the need for integrated strategies that incorporate both nutritional and pharmacological perspectives. Future research should focus on elucidating the precise mechanisms through which micronutrients influence drug metabolism and developing guidelines for optimizing drug therapy in the context of micronutrient status.