IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

MERCURY SUBSTRATE METHOD NOVEL APPROCH FOR FORMULATION OF DROTAVERINE HYDROCHLORIDE TRANSDERMAL PATCHES

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Bhambar Kunal V, Dr. Bhambar Rajendra S., Prof. Rutuja Aher
» doi: 10.48047/IJFANS/S1/117

Abstract

Background: Aim of the present investigation is to prepare sustained release transdermal patches of Drotaverine hydrochloride. Transdermal drug delivery has ability to bypass liver first pass metabolism and deliver the drug towards systemic circulation. Drotaverine hydrochloride is used to treat the spasticity as muscle relaxant. Methods: Mercury substrate method is utilized for formulation of Transdermal patches of Drotaverine Hydrochloride. Ethyl cellulose and Eudragit RL 100 were used to retard the drug release. Dibutyl phthalate used as plasticizer and Dichloromethane as a solvent solvent system. Transdermal patches were evaluated for physical appearance, weight variation, drug content, folding endurance, Fourier-transform infrared spectroscopy (FTIR), Differential scanning colourimetry (DSC) and invitro drug release study. Result: The DSC curve of transdermal patch (TDDS D3) shows a sharp endothermic peak at 208.17°C indicating crystalline structure. The dissolution curve shows that formulation TDDS D3 shows maximum drug release 83.57% at the end of 12 Hrs. Conclusion: For transdermal Patches according to ‘r’ value, Kors Meyer- Peppa’s model was the best suited for drug release but n value obtained from Kors Meyer- Peppa’s equation was within 0.5 -1.0 which indicates anomalous releases.

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