IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

Evaluation of the effect of Synbiotic in High-fat diet and streptozotocin induced diabetes in Wistar rats

Main Article Content

Wadulkar R. D, Bhusnure O.G

Abstract

Background: Dysbiosis is the causative factor chronic diseases including diabetes, obesity, cancer, and Inflammatory Bowel disease. Homeostasis of gut flora with prebiotics and probiotics could reduce the risk factors of chronic disease. Aim: To study the effect of Synbiotic (combination of prebiotics and probiotics) in a High-fat diet and STZ-induced diabetes in Rats. Methods and Material: In the present study we had designed the formulation containing sauerkraut juice as a good source of probiotics and prebiotics (Allium Sativum and Cucurbita maxima). The designed polyherbal formulation (PHF) in lower and higher concentrations was evaluated for antidiabetic and antiobesity activity in a High-fat diet and Streptozotocin-induced diabetes in Wistar rats. Results: Polyherbal formulation in lower concentration (PHF-LC) and Polyherbal formulation in high concentration (PHF-HC) reduced blood glucose significantly (p<0.01) & (p<0.001) respectively when compared to the Diabetic (HFD-STZ) control group and positive control group. Reference standard metformin most effectively (p<0.001) reduced the blood glucose level when compared to the Diabetic (HFD-STZ) control group. It also shows a significant reduction in the lipid profile and body weight of animals. The histopathological study clearly shows that polyherbal formulation in higher concentrations restores the normal architecture of the liver and pancreas Conclusions: It was concluded that polyherbal combination in higher concentrations shows significant antiobesity and antidiabetic effects in High fat and STZ-induced diabetic rats. The polyherbal formulation may prevent dysbiosis-induced diabetes and obesity in Wistar rats. But further preclinical and clinical evaluation is requieed for the clinical use of such formulation. Adding synbiotics to the diet could be a good approach to the prevention and treatment of chronic disease

Article Details