The pharmaceutical sector stands as a pivotal pillar within a robust healthcare system, an imperative facet for the well-being of societies and economies alike. However, a pressing concern lies in medication safety and security, attributed to the proliferation of counterfeit and substandard medical products. This precarious issue poses significant risks to consumers' health, casting a shadow over public welfare. On a global scale, the pervasive menace of drug counterfeiting poses a grave threat, engendering a sizeable illicit market that generates substantial revenue. Amidst this backdrop, the pharmaceutical industry assumes a paramount role, underpinning the provision of quality healthcare through the supply of medicines and pharmaceutical essentials.In tandem with the rapid advancement of transformative technologies, such as blockchain and the Internet of Things (IoT), that have permeated diverse industries, a systematic review of pertinent literature was undertaken in this study. This endeavor aimed to scrutinize and assess the diverse applications of these technologies within the pharmaceutical realm, while also examining existing frameworks tailored to address the industry's challenges.The synthesis of the literature underscored the potential of a hybrid framework that synergistically employs both blockchain and IoT technologies. This amalgamation holds the promise to alleviate the pressing issue of drug counterfeiting and offer multifaceted solutions to the spectrum of challenges encountered within the pharmaceutical domain. Furthermore, the study presented a novel framework that effectively tackled the limitations observed in prevailing frameworks within the pharmaceutical sector.. By doing so, the study not only advocates for the critical role of technological innovation but also extends a proposition for an integrated solution, paving the way for enhanced pharmaceutical safety and efficacy.