Plants have been used for medicine from time immemorial because they have fitted the immediate personal need, are easily accessible and inexpensive. In the recent past there has been a tremendous increase in the use of plant based health products in developing as well as developed countries resulting in an exponential growth of herbal products globally. Herbal medicines have a strong traditional or conceptual base and the potential to be useful as drugs in terms of safety and effectiveness leads for treating different diseases. Only preliminary studies have been reported for the antidiabetic activity of the leaves of Eclipta angustata. Therefore, an attempt has been made to evaluate the antidiabetic potential of the ethanolic extract of Eclipta angustata leaves in streptozotocin induced diabetic models. It was found that ethanol extract of the leaves of Eclipta angustata was active in STZ models in Sprague-Dawley(SD) rats.