Medicinal plants are gifts of nature to cure limitless diseases among human beings. It has been well known since ancient time that plant species have antibacterial activity. Elephantopus scaber is a tropical species of flowering plant in the sunflower family Asteraceae. It is native to tropical Africa, Eastern Asia, Indian Subcontinent, Southeast Asia, and Northern Australia. In folk medicinal practices, various parts of the plant and even the whole plant of E. scaber have been used in many countries for the treatment of a number of diseases. The Antibacterial activity was investigated by Disc diffusion method. The antibacterial activity of Elephantopus scaber Linn by using petroleum ether, ethanol and aqueous extract were examined against the bacteria Staphylococcus aureus, Klebsiella pneumoniae, E.coli, Proteus vulgaris and Entero bacter. The Elephantopus scaber showed effective zone of inhibition against the five bacterial pathogens. Therefore the Elephantopus scaber can be considered to be the promising source of antibacterial compounds.