Background: There is an increasing insist for natural drugs as continuous use of synthetic ones can culminate into many side effects and toxicity. Therefore, plant resources are of main concern for the scientists to search the alternate drugs for the liver ailments. Keeping in view the non-toxic nature of medicinal plant extracts, the present study was undertaken to evaluate the hepatoprotective potential of ethanol extract of Taraxacumofficinale (EETO) leaves in the rats intoxicated with the carbon tetrachloride. Results: The crude extract was given to the rats at two doses of 100 mg/kg and 200 mg/kg body weight for the duration of 30 days. The elevated levels of the serum biomarkers (by carbon tetrachloride intoxication, i.p.) such as aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), acid phosphatase (ACP) and total bilirubin were found to be significantly less and the level of total protein was significantly elevated in groups treated with ethanolic extract of T. officinale alongside carbon tetrachloride at two doses of 100 mg/kg and 200 mg/kg body weight. The histopathological studies also confirmed our biochemical results. Conclusion: The results of both biochemical and histopathological studies revealedthat the ethanolic extract of T. officinaleis decent enough to combat hepatic damage.