Microplastics have become a ubiquitous and persistent pollutant in the environment, with potential adverse effects on human health. This study aims to investigate the impact of microplastics on the ion channels and body cells in the development of chronic diseases such as cancer, cardiovascular disease, and neurodegenerative disease. The study focuses on the mechanisms by which microplastics interact with the human body, including their uptake, distribution, and effects on cellular and molecular processes. The study employs various methods, including in vitro and in vivo experiments, to evaluate the effects of microplastics on different biological systems. The study also explores the potential role of microplastics in the development of chronic diseases and the underlying molecular mechanisms. The findings from this study can contribute to a better understanding of the impact of microplastics on human health and inform the development of effective policies and regulations to limit their release into the environment.