Diabetes mellitus has been described as the most common endocrine disorder that impairs glucose homeostasis resulting in severe complications. Lipid abnormalities are commonly associated with diabetes. Currently, there is renewed interest in the plant based medicines. One such herbal drug, Aloe vera used for different clinical purposes claimed for its effect on blood glucose levels and lipid profile. Total of 240 newly diagnosed type 2 diabetes mellitus with hyperlipidaemia patients were allocated to group A and B. Group A received a combination of Metformin + Glimiperide with rosuvastatin and Aloe vera as add on therapy, while group B received combination of Metformin + Glimiperide with rosuvastatin. While assessing the results and comparing the overall degree of glycaemia control between group A & B, A significant (p < 0.001) difference with lower mean fasting (93.16 ± 2.54) and mean PP blood glucose (138.69 ± 3.45) were observed in group A and a significant (P < 0.0001) difference was also noted in the mean lipid profile recorded before starting the treatment when compared with the mean lipid profile after starting the treatment in patients who were treated with treatment regimen A. The study concluded that the subjects who were treated with drugs of group A has comparatively produced better clinical outcome in terms of glycaemia control and effect on increased lipids.