ANTIDYSLIPIDEMIC, ANTIHYPERLIPIDEMIC AND ANTIOXIDANT ACTIVITY OF AEGELINE ANALOGUES

Abstract

Abstract: Aegeline (V) from the leaves of Aegle marmelos as a dual acting agent (antihyperlipidemic and antihyperglycemic). Alkaloidal amides [N-(2-hydroxy-2-p-tolylethyl)-amides and N-(2-oxo-2-p-tolylethyl)-amide derivatives] and N-acylated-1-amino-3-aryloxy-2-propanols related to Aegeline and evaluated for their in vivo antihyperlipidemic activity in Triton induced hyperlipidemia model. These compounds showed equipotent activity to the natural product, that is, Aegeline (V). These compounds also showed strong antioxidant activity, which support their antihyperlipidemic activity. Few Compounds showed better antihyperlipidemic and antioxidant profile than the natural product Aegeline.