Stability And Invivo Studies Of Mucoadhesive Buccal Tablets (Repaglinide) For Management Of Diabetes

Abstract

Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus. The main objective of the study was to formulate and evaluate bioadhesive buccal tablets to avoid the first pass metabolism in liver. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesive polymers like HPMC K4 M, HPMC K15 M, Chitosan, HPMC K100 M, Sodium CMC, Carbopol 974 P, Sodium Alginate, Gum karaya and Carbopol 941NF in different ratios.