Review of the Pharmacology and Pharmacokinetics of Polydatin

Abstract

In addition to being found in grape, peanut, hop cones, red wines, hop pellets, cocoacontaining products, chocolate products, and many daily diets, polydatin, also known as piceid (3,40,5-trihydroxystilbene-3-b-D-glucoside, PD), is a monocrystalline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae). In the past 22 years, there have been many investigations on PD described, however they are typically dispersed across multiple publications, which may hinder future study and clinical use of PD. The article reviews and summarises the scientific literature on the pharmacological effects and pharmacokinetics of PD published since 1990. Major databases like MEDLINE, Elsevier, Springer, PubMed, Scholar, and CNKI were used to gather the data from the 98 cases that made up this review. Numerous pharmacological studies on PD mostly concentrate on cardiovascular effects, neuroprotection, antiinflammatory and immunoregulatory effects, anti-oxidation, anti-tumor, and liver and lung protection, among other things. In the past 22 years, numerous pharmacological and pharmacokinetic studies have shown that PD has excellent therapeutic qualities, showing its potential as a useful substance. However, more investigation is required to determine its precise target proteins and molecular mechanisms of action.