Dentigerous cyst is a commonest developmental Odontogenic cyst that grows by fluid collection over the top of an impacted crown and reduced enamel epithelium. Moreover, it is usually associated with impacted tooth and surrounding the crown of the tooth. But, this case report highlights a well-defined radiolucent lesion in the body of the mandible which is not associated to an impacted wisdom tooth or any other tooth in radiographical representation. Furthermore, histological examination demonstrates reduced enamel like epithelium and it was conformed as dentigerous cyst. The histological feature also revealed ameloblastomatous transformation along with cholesterol clefts and calcification in the lumen which rarely occurs with the dentigerous cyst making it unique. Therefore, a conformed diagnosis is necessary that can be done by microscopical examination to take appropriate therapeutic decision.