Transgenders who have become third genders are the most pressing issues today, despite the many demands and sufferings of many sentences. Transgender people struggle with the thoughts of fulfilling their desires and dreams to live a normal life, to be accepted in the society, to act like fellow human beings. The community views transgender people only as talking points: beggars for money, sex workers, ridiculous people, whimsical humans and physical and psychological study manuals.In this situation, only a few people accept their true status and accept them as fellow human beings and a few transgender people know themselves as normal human being.The majority of people in society do not accept transgender people as normal human beings, and they do not welcome and encourage transgender entrepreneurs. But some of the transgender people are walking with the thoughts of getting their own recognition and getting their belongings without ever giving up their self-confidence. So they are more confident and stand on their own legs through entrepreneurship. As a part of that path, this study has been carried out as a collection of challenges faced during the start-up phase of the business cycle of transgender people who are self-employed in Tamil Nadu.