Corona viruses are enveloped viruses with appositive sense ,single strand RNA genome.Corona virus spike protein has been reported as significant part of the virus host cell entry.SARS –Cov-2 bind to the human angiotensin converting enzyme-2(ACE_2)through the viral spike protein ,which triggers the entry of infectious SARS-CoV-2.ACE -2 is a cardio cerebral vascular protection factor found in many tissues, including kidney,Intestine,Lungs,skeletol muscles and Nervous system.Besides, it’s played an important role in regulating blood pressure and arteriosclerosis mechanism as well as it consider a major binding target for SARS-CoV-2 spike protein of COVID -19 . Total of 10 bioactive lead compounds were retrieved from the herbs present in the formulations. From reported data of the herb, the lead molecules such as Vaccenic acid, Aloin-A and Aloe-emodin possess 100% binding efficacy by interacting with both the core target amino acids (31 LYS and 353 LYS) present on the target. Followed by this other phytocompounds such as Cinnamic acid, Grandisin, LicarinA, Elemicin and Gibberellic acid possess 50% affinity by binding with one of the target amino acid either with 31 LYS or with 353 LYS present on the target receptor ACE-2.[12]