Maintaining optimal soil pH is essential for maximizing agricultural productivity and ecosystem health. This paper examines the intricate relationship between soil pH levels and plant nutrient uptake. It synthesizes existing research to elucidate how soil pH influences the availability of essential nutrients such as nitrogen, phosphorus, potassium, and micronutrients to plants. The impacts of soil pH on plant growth, development, and overall health are discussed, highlighting the mechanisms through which pH affects nutrient solubility, microbial activity, and root physiology. Strategies for managing soil pH to mitigate nutrient deficiencies or toxicities are reviewed, emphasizing the importance of precision agriculture and sustainable practices. Future research directions are proposed to enhance our understanding and application of soil pH management in optimizing agricultural sustainability and food security.