Volume 13 | Issue 4
Volume 13 | Issue 4
Volume 13 | Issue 4
Volume 13 | Issue 4
Volume 13 | Issue 4
The lutein extracted from shade-dried Tagetes erecta flower petal powder by simultaneous solvent extraction and saponification was exposed to sunlight (31±2ºC) for 10 days. Bioavailability and absorption kinetics of total lutein oxidised products in comparison with lutein (parent molecule) were analysed on C57BL/6 mice. Time course plasma kinetics was studied by collecting blood, liver, intestine and eyes after the 1st, 2nd, 3rd, 6th and 9th hour of intubation. The oral bioavailability of total lutein oxidized products was enhanced in contrast to lutein in plasma by 25% (2nd hr), liver by 11% and eyes by 55%. The plasma kinetic properties like area under concentration and area under moment concentration of total lutein oxidized products were 1139.418 pg/h/ml and 17750.69pg/h2/ml respectively with a half-life of 11.353h. The mean residence time of total lutein oxidized products was 15.573h with a volume of distribution of 2.874 and clearance of 0.175. The concentration of total lutein oxidized products in eyes at the 9th hour was 59.80pg/ml. Whereas, the mean lutein concentration in plasma, liver, and eye was significantly less in lutein in comparison with total lutein oxidized products. Thus, the above data suggest that total lutein oxidized products reach target tissue unaltered and enhance the absorption rate in comparison to the parental compound lutein.