Plant breeding is one method of addressing the issue of bridging the increasing gap between food demand and availability. But plant breeding has its own detrimental side effects, despite the significance. Relocation of landraces with a number of genetically identical species makes genetic diversity less common and offers perfect circumstances for genetically vulnerable illnesses and insect pests. The ever-growing human population and consequently rising needs for more food are the major drive toward that limited genetic basis, on the one hand, and the success of initiatives such as the Green Revolution by adopting genetically unified variety in many areas of the globe on the other. It is essential, then, to understand the phenomena and prepare to reduce the dangers of hereditary susceptibility. The current plant breeding strategy, variety releases and certification procedures leading to genetic uniformity should be reconsidered under marginal conditions under which the resource-poor farmers are dominated and some level of genetic diversity should be deliberately maintained within the variety development programmes. Genetic variety may be introduced at many levels and in a range of methods including intra-varietal, inter-varietal, parental and inter-specific diversities. A systemic geographical and temporal application of genetics, the utilization of interspecific varietal mixes and the integration of horizontal and vertical resistors have been proposed as a method for specific adaptation rather than broad adaptation.