The present study was aimed to investigate the hepatotoxicity induced by cypermethrin and sodium fluoride (NaF) separately and combined in albino mice. Albino mice were treated at 48-hr intervals with cypermethrin and sodium fluoride (NaF), separately and in combination, for 15 and 30 days with 1/10th of the LD50 dosage of cypermethrin and NaF for individual administration by oral gavage (i.e., 8.5 mg/kg bw and 5.6 mg/kg bw, respectively) and 1/20th of the LD50 dose of cypermethrin and NaF for combined administration (i.e., 4.25 mg/kg bw and 2.8 mg/kg bw, respectively). Separate or combined treatment resulted in histopathological changes in the liver tissue such as cytoplasmic degeneration, cellular disarray, binucleated condition, vacuolar and nuclear degeneration in the hepatocytes were observed. The changes were greater in combination than individual treatment, this may be because of a synergistic effect of cypermethrin and NaF.