IJFANS International Journal of Food and Nutritional Sciences

ISSN PRINT 2319 1775 Online 2320-7876

SCREENING OF ANTICANCER ACTIVITY OF METHANOL EXTRACT OF COCOS NUCIFERA INFLORESCENCE IN SK-MEL CELL LINES

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ANITHA.C AND Dr. P.A MARY HELEN

Abstract

Cocos nucifera (L.) is an important member of the family Arecaceae (palm family) popularly known as coconut, coco, coco-da-bahia, or coconut-of-the-beach .The plant is originally from Southeast Asia (Malaysia, Indonesia, and the Philippines) and the islands between the Indian and Pacific Oceans. The present study was intended to screen the anticancer activity of methanol extract of Cocos nucifera inflorescence against SK-MEL cell lines. The percentage of cell viability showed 6.25 µg/mL, 12.5 µg/mL,25 µg/mL,50 µg/mL,100 µg/mL such as 91.63 %, 85.86 %, 74.31 %, 61.18 %, 48.05 % respectively and the cytotoxic effects of cell line showed the percentage of cytotoxicity such as 8.37%, 14.14%, 25.69%, 38.82% and 51.95% respectively. Dose dependent reduction in cell viability was observed in SK-MEL cancer cells administered with different concentrations of the sample. The IC50 value was obtained as 98.49µg/mL of the sample. The results showed that Cocos nucifera inflorescence extracts have intresting pharmacological active compounds and used in ethnomedicine for treatment of various diseases.

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